However, as the abundance of progenitor cells varies between different tissues and in the same tissue during the fetal, neonatal and adult stages of development, the scarcity of a particular progenitor cell pool, the paucity of spontaneous departures of progenitor cells down differentiation pathways and unclear differentiation induction conditions can complicate genetic therapeutic intervention via these cells. The defective cells requiring treatment are typically differentiated these cells or their progenitors can be targeted for therapeutic gene transfer. The treatment of a number of diseases can be achieved through gene addition therapy, where curative transgenes are established within the patient’s cells after delivery with viral or non-viral vectors.
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